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Back to Cardiology Drug index
Brand Name:
Lescol
Name: Fluvastatin
Pregnancy Category X
Drug classes of Lescol
Mechanism of action of Lescol
A fungal metabolite that inhibits the enzyme HMG-CoA that catalyzes
the first step in the cholesterol synthesis pathway, resulting in a
decrease in serum cholesterol, serum LDLs (associated with increased
risk of
coronary artery disease), and
either an increase or no change in serum HDLs (associated with decreased
risk of
coronary artery disease).
Indications of Lescol
- As an adjunct to diet in the treatment of elevated total cholesterol
and LDL cholesterol in patients with primary hypercholesterolemia (types
IIa and IIb) whose response to dietary restriction of saturated fat and
cholesterol and other nonpharmacologic measures has not been adequate.
Contraindications of Lescol
- Allergy to fluvastatin
- Fungal byproducts
- Pregnancy
- Lactation
Use caution in the presence of impaired hepatic function, cataracts.
Adverse effects of Lescol
- CNS:
Headache, blurred vision,
dizziness, insomnia, fatigue, muscle cramps, cataracts
- GI: Flatulence,
abdominal pain, cramps,
constipation,
nausea,
dyspepsia, heartburn
- Hematologic: Elevations of
CPK,
alkaline phosphatase and
transaminiases
- Neuromuscular: Myopathy, rhabdomyolysis
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