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Olivopontocerebellar degeneration (OPCD)

A loose group of uncommon progressive degenerative disorders that cause cerebellar dysfunction with or without other motor or sensory affection.

Pathologically the most common denominator in this category is degenerative changes in the pons, olive and cerebellum.

The condition in the 40-60 (as early as 20) age group. There is no sexual predilection. The condition is autosomal dominant.

Clinical suspicion

Patient presents with any combination of the following dysfunctions:

  • Cerebellar dysfunctions
  • Nystagmus 
  • Pyrmaidal tract lesions
  • Parkinsonian signs 
  • Dementia
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MRI shows degeneration in advanced cases.


Is mainly symptomatic.

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